|Full Name||neuroblastoma RAS viral (v-ras) oncogene homolog|
|Product Description||Goat polyclonal antibody to N-Ras|
|Background||This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]|
|Synonyms||NRAS Antibody , NRAS1 Antibody , N-RAS Antibody , ALPS4 Antibody , NS6 Antibody|
|Cellular Localization||Shuttles between the plasma membrane and the Golgi apparatus. |
|Specificity||This antibody is specific for N-RAS, and it does not cross react with human K-Ras and H-Ras protein.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.