|Product Description||Rabbit Polyclonal antibody to NBS1 (nibrin)|
|Background||Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq]|
|Synonyms||AT-V1 Antibody, nibrin Antibody, NBN Antibody, P95 Antibody, AT-V2 Antibody, ATV Antibody, NBS Antibody|
|Cellular Localization||Nucleus (By similarity) , Telomere (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human NBS1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (94%)|