|Full Name||neutrophil cytosolic factor 4, 40kDa|
|Product Description||Rabbit Polyclonal antibody to NCF4 (neutrophil cytosolic factor 4, 40kDa)|
|Background||The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]|
|Synonyms||MGC3810 antibody, NCF antibody, P40PHOX antibody, SH3PXD4 antibody, NCF4 antibody, p40-phox antibody, neutrophil NADPH oxidase factor 4 antibody, neutrophil cytosol factor 4 antibody, NCF-4 antibody, SH3 and PX domain-containing protein 4 antibody, "neutrophil cytosolic factor 4, 40kDa antibody"|
|Immunogen||Full length human NCF4 Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Mouse, Rat, Rabbit|
|Predict Reactivity Note||Bovine (89%), Mouse (86%), Rat (87%), Rabbit (90%)|