|Full Name||nuclear receptor coactivator 2|
|Product Description||Rabbit Polyclonal antibody to NCOA2 (nuclear receptor coactivator 2)|
|Background||The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM]|
|Synonyms||GRIP1 antibody, KAT13C antibody, MGC138808 antibody, NCoA-2 antibody, SRC2 antibody, TIF2 antibody, bHLHe75 antibody, NCOA2 antibody, class E basic helix-loop-helix protein 75 antibody, nuclear receptor coactivator 2 antibody, glucocorticoid receptor-interacting protein-1 antibody, transcriptional intermediary factor 2 antibody, hTIF2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human NCOA2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig|
|Predict Reactivity Note||Mouse (89%), Rat (93%), Pig (95%)|