|Full Name||nudE nuclear distribution gene E homolog (A. nidulans)-like 1|
|Product Description||Goat polyclonal antibody to NDEL1|
|Background||Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. |
|Synonyms||MITAP1, NUDElike prote, nudE nuclear distribution gene E homolog like1, nudE nuclear distribution gene E homolog (A. nidulans)-like 1, EOPA, DKFZp451M0318, nudE nuclear distribution gene E homolog (A. nidulans)like 1, endooligopeptidase A, NDEL1, nudE nuclear distribution gene E homolog like 1, nudE nuclear distribution gene E homolog (A. nidulans)like1, NUDE-like prote, NUDEL, NUDE like prote|
|Cellular Localization||Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the |
|Specificity||This antibody is specific for NDEL1.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|