|Full Name||nuclear factor (erythroid-derived 2), 45kDa|
|Product Description||Rabbit Polyclonal antibody to NF-E2 (nuclear factor (erythroid-derived 2), 45kDa)|
|Background||Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.|
|Synonyms||NF-E2 antibody, p45 antibody, NFE2 antibody, leucine zipper protein NF-E2 antibody, transcription factor NF-E2 45 kDa subunit antibody, "nuclear factor, erythroid-derived 2 45 kDa subunit antibody", p45 NF-E2 antibody, "nuclear factor (erythroid-derived 2), 45kDa antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human NF-E2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (90%), Pig (91%), Rhesus Monkey (97%), Bovine (90%)|