|Full Name||nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p100)|
|Product Description||Rabbit Polyclonal antibody to NFkB p100 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2)|
|Background||NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM]|
|Synonyms||LYT-10 antibody, LYT10 antibody, p52 antibody, NFKB2 antibody, nuclear factor NF-kappa-B p100 subunit antibody, nuclear factor of kappa light chain gene enhancer in B-cells 2 antibody, oncogene Lyt-10 antibody, DNA-binding factor KBF2 antibody, lymphocyte translocation chromosome 10 protein antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) antibody|
|Cellular Localization||Nucleus , Cytoplasm |
|Specificity||GTX101150 specifically recognizes NFkB p100 isoform, but not the cleaved p52 isoform.|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human NFkB p100. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (90%), Bovine (85%)|