NFkB p105 antibody
|Applications||ICC/IF, IHC, IHC-P, WB, ChIP assay|
Not tested in other applications.
| ChIP assay||Assay-dependent dilution
| Immunohistochemistry||Assay-dependent dilution
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||105 kDa (note)
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||nuclear factor of kappa light polypeptide gene enhancer in B-cells 1|
|Product Description||Rabbit Polyclonal antibody to NFkB p105 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)|
|Background||This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. [provided by RefSeq]|
|Synonyms||DKFZp686C01211 antibody, EBP-1 antibody, KBF1 antibody, MGC54151 antibody, NF-kappa-B antibody, NF-kappaB antibody, NFKB-p105 antibody, p105 antibody, NFKB1 antibody, nuclear factor kappa-B DNA binding subunit antibody, NF-kappabeta antibody, nuclear factor NF-kappa-B p105 subunit antibody, DNA-binding factor KBF1 antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody|
|Cellular Localization||Nucleus , Cytoplasm |
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (89%), Dog (94%), Pig (93%), Rhesus Monkey (99%), Bovine (92%)|