|Full Name||v-rel reticuloendotheliosis viral oncogene homolog A (avian)|
|Product Description||Mouse monoclonal [112A1021] to NFkB p65|
|Background||The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T-cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's disease, atherosclerosis and cancer.|
|Synonyms||MGC131774, NFKB3, p65|
|Immunogen||Synthetic peptide: GLLSGDEDFSSIAD, corresponding to amino acids 526-539 of Human NFkB p65.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Chimpanzee, Dog, Gorilla, Monkey, Pig|
|Predict Reactivity Note||Bovine(100%), Gorilla (100%), Monkey (100%), Pig (100%), Dog (100%), Chimpanzee (100%)|