|Full Name||notch 2|
|Product Description||Rabbit polyclonal antibody to NOTCH2 (Notch homolog 2 (Drosophila))|
|Background||This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq]|
|Synonyms||AGS2 antibody, hN2 antibody, NOTCH2 antibody, neurogenic locus notch homolog protein 2 antibody, Notch homolog 2 antibody, notch 2 antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein , Notch 2 intracellular domain: Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human NOTCH2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey|
|Predict Reactivity Note||Rat (89%), Rhesus Monkey (99%)|