|Full Name||notch 3|
|Product Description||Goat polyclonal antibody to NOTCH3|
|Background||Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. |
|Synonyms||Notch homolog 3 (Drosophila), HGNC:7883, Notch homolog3 (Drosophila), Notch homolog 3, CADASIL, NOTCH3, CASIL, Notch (Drosophila) homolog3, Notch homolog3, Notch (Drosophila) homolog 3|
|Cellular Localization||Following proteolytical processing NICD is translocated to the nucleus. |
|Specificity||This antibody is specific for NOTCH3.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat|