|Full Name||NADPH oxidase 4|
|Product Description||Rabbit Polyclonal antibody to NOX4 (NADPH oxidase 4)|
|Background||This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.|
|Synonyms||KOX antibody, KOX-1 antibody, RENOX antibody, NOX4 antibody, renal NAD(P)H-oxidase antibody, NADPH oxidase 4 antibody, kidney superoxide-producing NADPH oxidase antibody, kidney oxidase-1 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein , Cell membrane; Multi-pass membrane protein (Probable) , Cell junction , focal adhesion (Probable) , Nucleus (Probable) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human NOX4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chicken (84%), Bovine (96%)|