| Full Name | NAD(P)H dehydrogenase, quinone 1 |
| Background | This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Synonyms | DHQU antibody, DIA4 antibody, DTD antibody, NMOR1 antibody, NMORI antibody, QR1 antibody, NQO1 antibody, phylloquinone reductase antibody, dioxin-inducible 1 antibody, azoreductase antibody, NAD(P)H:Quinone acceptor oxidoreductase type 1 antibody, quinone reductase 1 antibody, NAD(P)H:quinone oxidoreductase 1 antibody, NAD(P)H:menadione oxidoreductase 1 antibody, diaphorase-4 antibody, diaphorase (NADH/NADPH) (cytochrome b-5 reductase) antibody, NAD(P)H dehydrogenase [quinone] 1 antibody, menadione reductase antibody, NAD(P)H:quinone oxireductase antibody, DT-diaphorase antibody, NAD(P)H dehydrogenase, quinone 1 antibody |
| Cellular Localization | Cytoplasm |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human NQO1. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rat, Pig, Rhesus Monkey, Bovine, Guinea pig |
| Predict Reactivity Note | Rat (83%), Pig (92%), Rhesus Monkey (98%), Bovine (92%), Guinea pig (86%) |
| Conjugation | Unconjugated |