|Full Name||nuclear receptor subfamily 0, group B, member 2|
|Product Description||Rabbit Polyclonal antibody to NR0B2 (nuclear receptor subfamily 0, group B, member 2)|
|Background||The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq]|
|Synonyms||FLJ17090 antibody, SHP antibody, SHP1 antibody, NR0B2 antibody, orphan nuclear receptor SHP antibody, small heterodimer partner antibody, nuclear receptor SHP antibody, nuclear receptor subfamily 0 group B member 2 antibody, "nuclear receptor subfamily 0, group B, member 2 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human NR0B2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (80%)|