|Full Name||N-terminal asparagine amidase|
|Product Description||Rabbit Polyclonal antibody to NTAN1 (N-terminal asparagine amidase)|
|Background||Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position.|
|Synonyms||DKFZp666E058 antibody, NTAN1 antibody, PNAA antibody, protein NTN-amidase antibody, protein NH2-terminal asparagine deamidase antibody, protein NH2-terminal asparagine amidohydrolase antibody, protein N-terminal Asn amidase antibody, PNAD antibody, protein N-terminal asparagine amidohydrolase antibody, N-terminal asparagine amidohydrolase antibody, N-terminal asparagine amidase antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human NTAN1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (95%), Pig (93%), Bovine (93%)|