|Full Name||numb homolog (Drosophila)-like|
|Product Description||Rabbit polyclonal antibody to Numb-R (numb homolog (Drosophila)-like)|
|Background||Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.|
|Synonyms||CAG3A antibody, CTG3a antibody, NBL antibody, NUMB-R antibody, NUMBLIKE antibody, NUMBR antibody, TNRC23 antibody, NUMBL antibody, numb-like protein antibody, numb-related protein antibody, numb homolog-like antibody, numb homolog (Drosophila)-like antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human NUMBL. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Bovine (86%)|