|Full Name||Nanog homeobox|
|Product Description||Goat Polyclonal antibody to Nanog|
|Background||Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation. |
|Synonyms||homeobox transcription factor Nanogdelta 48, homeobox transcription factor Nanogdelta48, Nanog homeobox, homeobox transcription factor Nanog-delta 48, HGNC:20857, NANOG, homeobox transcription factor Nanog|
|Specificity||This antibody is specific for NANOG.|
|Species Reactivity||Human, Pig|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.