Neuroserpin antibody [N1C1]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||46 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||serpin peptidase inhibitor, clade I (neuroserpin), member 1|
|Product Description||Rabbit Polyclonal antibody to Neuroserpin (serpin peptidase inhibitor, clade I (neuroserpin), member 1)|
|Background||This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]|
|Synonyms||DKFZp781N13156 antibody, PI12 antibody, neuroserpin antibody, SERPINI1 antibody, PI-12 antibody, peptidase inhibitor 12 antibody, serpin I1 antibody, "serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 antibody", "serpin peptidase inhibitor, clade I (neuroserpin), member 1 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Neuroserpin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (85%), Rhesus Monkey (96%), Bovine (88%)|