|Product Description||Rabbit Polyclonal antibody to Nicastrin (nicastrin)|
|Background||This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq]|
|Synonyms||APH2 antibody, KIAA0253 antibody, NCSTN antibody, nicastrin antibody, anterior pharynx-defective 2 antibody, ATAG1874 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein (Potential) , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Nicastrin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (92%), Rat (92%), Dog (94%), Rhesus Monkey (100%), Bovine (89%)|