|Full Name||NK2 transcription factor related, locus 5 (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to Nkx2.5 (NK2 transcription factor related, locus 5 (Drosophila))|
|Background||Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM]|
|Synonyms||CHNG5 antibody, CSX antibody, CSX1 antibody, FLJ52202 antibody, FLJ97166 antibody, FLJ97195 antibody, FLJ97197 antibody, FLJ99536 antibody, NKX2.5 antibody, NKX2E antibody, NKX4-1 antibody, NKX2-5 antibody, tinman paralog antibody, homeobox protein Nkx-2.5 antibody, cardiac-specific homeobox 1 antibody, NK2 transcription factor related, locus 5 antibody, homeobox protein NK-2 homolog E antibody, homeobox protein CSX antibody, NK2 transcription factor related, locus 5 (Drosophila) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Nkx2.5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Bovine|
|Predict Reactivity Note||Rat (86%), Dog (93%), Bovine (93%)|