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1 .GTX85292 Norrin antibody

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Norrin antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsELISA, ICC/IF, WB
  • Species reactivityHuman
Cat No: GTX85292
Package Price Qty
100 μgUSD 329.00
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  • Anti-Norrin antibody used in Western Blot (WB). GTX85292
  • Anti-Norrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85292
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  • Datasheet
  • Application Information: Norrin antibody

Catalog Number GTX85292
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Product Name Norrin antibody
See all Norrin products
ApplicationsELISA, ICC/IF, WB
Application Note
Suggested dilutionReference
ELISAAssay-dependent dilution  
Immunocytochemistry/ Immunofluorescence (ICC/IF)5 μg/mL*  
Western Blot (WB)1 - 2 μg/mL*  
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Positive ControlsJurkat Cell Slide(GTX25533) , Jurkat Cell Lysate(GTX27899)
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by antigen-affinity chromatography

  • Specifications: Norrin antibody

Full NameNorrie disease (pseudoglioma)
BackgroundNorrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
SynonymsNDP, EVR2, ND, Norrie disease protein, FEVR, Norrin
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenNorrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin.The immunogen is located within the first 50 amino acids of Norrin.
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: Norrin antibody

Storage BufferPBS with 0.02% sodium azide.
Storage InstructionKeep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20° C or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Neuroscience > Sensory > Visual
  • Neuroscience > Signaling > Wnt singnaling
  • Signal Transduction > Growth Factors/Hormones
  • Signal Transduction > Signaling through proteolysis > Wnt
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Norrin antibody validated data
  • Anti-Norrin antibody used in Western Blot (WB). GTX85292
    • GTX85292 WB Image
      WB analysis of Jurkat cell lysate using GTX85292 Norrin antibody.
      Working concentration : (A) 1 and (B) 2 μg/ml
      Top
  • Anti-Norrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85292
    • GTX85292 ICC/IF Image
      ICC/IF analysis of Jurkat cells using GTX85292 Norrin antibody.
      Working concentration : 5 μg/ml
      Top
  • Anti-Norrin antibody used in Western Blot (WB). GTX85292
    • GTX85292 WB Image
      WB analysis of Jurkat cell lysate using GTX85292 Norrin antibody.
      Working concentration : (A) 1 and (B) 2 μg/ml
      Top
  • Anti-Norrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85292
    • GTX85292 ICC/IF Image
      ICC/IF analysis of Jurkat cells using GTX85292 Norrin antibody.
      Working concentration : 5 μg/ml
      Top
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All products are for research use only—Not for use in diagnostic procedures.