|Full Name||notch 3|
|Product Description||Rabbit polyclonal antibody to NOTCH3 (Notch homolog 3 (Drosophila))|
|Background||This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq]|
|Synonyms||CADASIL antibody, CASIL antibody, NOTCH3 antibody, neurogenic locus notch homolog protein 3 antibody, Notch homolog 3 antibody, notch 3 antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein , Notch 3 intracellular domain: Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human NOTCH3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (100%), Rat (100%)|