|Full Name||nucleophosmin (nucleolar phosphoprotein B23, numatrin)|
|Product Description||Goat polyclonal antibody to Nucleophosmin / NPM1|
|Background||Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. |
|Synonyms||numatrin, MGC104254, nucleophosmin 1, nucleophosmin1, Nucleophosmin / NPM1, nucleophosmin/nucleoplasmin family, member1, nucleophosmin/nucleoplasmin family, member 1, nucleophosmin (nucleolar phosphoprotein B23, numatrin), NPM, nucleolar phosphoprotein B23, B23, NPM1|
|Cellular Localization||Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle |
|Specificity||This antibody is specific for Nucleophosmin / NPM1.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.