OGDH antibody [C2C3], C-term
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||116 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , Mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)|
|Product Description||Rabbit Polyclonal antibody to OGDH (oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide))|
|Background||This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. [provided by RefSeq]|
|Synonyms||AKGDH antibody, E1k antibody, OGDC antibody, OGDH antibody, oxoglutarate dehydrogenase (succinyl-transferring) antibody, oxoglutarate decarboxylase antibody, OGDC-E1 antibody, 2-oxoglutarate dehydrogenase complex component E1 antibody, "2-oxoglutarate dehydrogenase, mitochondrial antibody", oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) antibody|
|Cellular Localization||Mitochondrion matrix|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human OGDH. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Bovine|
|Predict Reactivity Note||Rat (93%), Chicken (87%), Bovine (97%)|