|Full Name||optic atrophy 1 (autosomal dominant)|
|Product Description||Rabbit Polyclonal antibody to OPA1 (optic atrophy 1 (autosomal dominant))|
|Background||This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||NTG Antibody , NPG Antibody , largeG Antibody , optic atrophy 1 (autosomal dominant) Antibody , MGM1 Antibody|
|Cellular Localization||Mitochondrion inner membrane; Single-pass membrane protein , Mitochondrion intermembrane space |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human OPA1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Zebrafish, Chicken, Bovine|
|Predict Reactivity Note||Human (100%), Rat (98%), Zebrafish (90%), Chicken (96%), Bovine (98%)|