|Applications||FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB|
|Application Note||WB: Use at a dilution of 1/500-1000.|
ICC/IF: Use at a dilution of 1/100-200.
IHC-P: Use at a dilution of 1/100.
IHC-Fr: Use at a dilution of 1/25-100.
IP: Use at a dilution of 1/10-500.
Predicted molecular weight: 39 kDa. Optimal dilutions/concentrations should be determined by the end user.
|Positive Controls||Jurkat whole cell extracts|
(Please refer to the vial label for the specific concentration)|
|Purification||Immunogen affinity purified|
|Full Name||8-oxoguanine DNA glycosylase|
|Product Description||Rabbit polyclonal to Ogg1|
|Background||This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.|
|Synonyms||HMMH, HOGG1, MUTM, OGH1|
|Specificity||This antibody is specific for hOgg1.|
|Immunogen||Synthetic peptide: CTVYRGDKSQASRPT conjugated to KLH, corresponding to amino acids 65-79 of Human Ogg 1.|
|Species Reactivity||Human, Mouse, Rat|