|Full Name||ATP-binding cassette, sub-family B (MDR/TAP), member 1|
|Product Description||Rabbit Polyclonal antibody to P Glycoprotein (ATP-binding cassette, sub-family B (MDR/TAP), member 1)|
|Background||The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]|
|Synonyms||ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, MGC163296 antibody, P-GP antibody, PGY1 antibody, ABCB1 antibody, doxorubicin resistance antibody, P-glycoprotein 1 antibody, multidrug resistance protein 1 antibody, colchicin sensitivity antibody, "ATP-binding cassette, sub-family B (MDR/TAP), member 1 antibody"|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human P Glycoprotein. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (93%)|