|Full Name||purinergic receptor P2X, ligand-gated ion channel, 7|
|Product Description||Rabbit Polyclonal antibody to P2X7 (purinergic receptor P2X, ligand-gated ion channel, 7)|
|Background||The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]|
|Synonyms||MGC20089 antibody, P2X7 antibody, P2RX7 antibody, P2Z receptor antibody, P2X7 receptor antibody, P2X purinoceptor 7 antibody, ATP receptor antibody, purinergic receptor P2X7 variant A antibody, "purinergic receptor P2X, ligand-gated ion channel, 7 antibody"|
|Cellular Localization||Membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human P2X7. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Bovine, Guinea pig|
|Predict Reactivity Note||Dog (92%), Bovine (86%), Guinea pig (83%)|