|Full Name||poly(A) binding protein, cytoplasmic 4 (inducible form)|
|Product Description||Rabbit Polyclonal antibody to PABPC4 (poly(A) binding protein, cytoplasmic 4 (inducible form))|
|Background||Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||APP-1 antibody, APP1 antibody, FLJ43938 antibody, PABP4 antibody, iPABP antibody, PABPC4 antibody, PABP-4 antibody, polyadenylate-binding protein 4 antibody, inducible poly(A)-binding protein antibody, activated-platelet protein 1 antibody, poly(A)-binding protein 4 antibody, "poly(A) binding protein, cytoplasmic 4 (inducible form) antibody"|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PABPC4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Bovine|
|Predict Reactivity Note||Rat (96%), Zebrafish (90%), Xenopus laevis (91%), Bovine (98%)|