PAI-1 antibody [N1C2]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||45 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji , NIH-3T3|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|
|Product Description||Rabbit Polyclonal antibody to PAI-1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1)|
|Background||This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||PAI antibody, PAI-1 antibody, PAI1 antibody, PLANH1 antibody, SERPINE1 antibody, "serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 antibody", serpin E1 antibody, endothelial plasminogen activator inhibitor antibody, plasminogen activator inhibitor 1 antibody, "serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 antibody"|
|Cellular Localization||Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PAI-1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Sheep, Bovine|
|Predict Reactivity Note||Rat (84%), Dog (89%), Pig (90%), Sheep (88%), Bovine (88%)|