Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||47 kDa (note)
|Positive Controls||Jurkat , Raji , K562 , THP-1 , HL-60 , NCI-H929|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase|
|Product Description||Rabbit Polyclonal antibody to PAICS (multifunctional protein ADE2)|
|Background||This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ADE2 antibody, ADE2H1 antibody, AIRC antibody, DKFZp781N1372 antibody, MGC1343 antibody, MGC5024 antibody, PAIS antibody, PAICS antibody, multifunctional protein ADE2 antibody, SAICAR synthetase antibody, multifunctional protein ADE2H1 antibody, AIR carboxylase antibody, "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PAICS. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (95%), Zebrafish (82%), Xenopus laevis (86%), Chicken (90%), Bovine (95%)|