|Full Name||p21 protein (Cdc42/Rac)-activated kinase 3|
|Product Description||Rabbit Polyclonal antibody to PAK3 (serine/threonine-protein kinase PAK 3)|
|Background||PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]|
|Synonyms||CDKN1A antibody, MRX30 antibody, MRX47 antibody, OPHN3 antibody, PAK3beta antibody, bPAK antibody, hPAK3 antibody, PAK3 antibody, p21 (CDKN1A)-activated kinase 3 antibody, oligophrenin-3 antibody, p21-activated kinase 3 antibody, serine/threonine-protein kinase PAK 3 antibody, beta-PAK antibody, PAK-3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PAK3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (100%), Chimpanzee (100%), Bovine (100%)|