|Full Name||p21 protein (Cdc42/Rac)-activated kinase 4|
|Product Description||Rabbit Polyclonal antibody to PAK4 (p21 protein (Cdc42/Rac)-activated kinase 4)|
|Background||PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||PAK4 antibody, PAK-4 antibody, "protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs antibody", p21(CDKN1A)-activated kinase 4 antibody, p21-activated kinase 4 antibody, serine/threonine-protein kinase PAK 4 antibody, p21 protein (Cdc42/Rac)-activated kinase 4 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PAK4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Zebrafish (94%), Bovine (99%)|