|Full Name||poly(A)-specific ribonuclease (deadenylation nuclease)|
|Product Description||Rabbit Polyclonal antibody to PARN (poly(A)-specific ribonuclease (deadenylation nuclease))|
|Background||The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DAN antibody, PARN antibody, deadenylation nuclease antibody, deadenylating nuclease antibody, poly(A)-specific ribonuclease (deadenylation nuclease) antibody, poly(A)-specific ribonuclease PARN antibody, polyadenylate-specific ribonuclease antibody|
|Cellular Localization||Nucleus , Cytoplasm , nucleolus |
|Specificity||Knockdown/Knockout validation was supported by references (PMID:26991009)|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PARN. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (86%), Bovine (98%)|