|Full Name||poly (ADP-ribose) polymerase 1|
|Product Description||Mouse Monoclonal antibody [GT982] to PARP1 (poly (ADP-ribose) polymerase 1)|
|Background||This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq]|
|Synonyms||ADPRT 1 Antibody , poly (ADP-ribose) polymerase 1 Antibody , PARP Antibody , ADPRT1 Antibody , ARTD1 Antibody , PARP-1 Antibody , ADPRT Antibody , PPOL Antibody , pADPRT-1 Antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PARP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (85%), Bovine (87%)|