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1 .GTX24831 PARP (cleaved) antibody (FITC)

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PARP (cleaved) antibody (FITC)


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsFACS
  • Species reactivityHuman, Bovine
Cat No: GTX24831
Package Price Qty
500 μlUSD 289.00
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  • Anti-PARP (cleaved) antibody (FITC) used in Flow cytometry/FACS. GTX24831
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  • Datasheet
  • Application Information: PARP (cleaved) antibody (FITC)

Catalog Number GTX24831
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Product Name PARP (cleaved) antibody (FITC)
See all PARP (cleaved) products
ApplicationsFACS
Application NoteFACS: Use at an assay dependant dilution. The unconjugated antibody to cleaved PARP (GTX24830) has been used successfully for Western blotting and immunohistochemistry applications. Optimal dilutions/concentrations should be determined by the end user.
Form SuppliedLiquid
PurificationImmunogen affinity purified
Purification NotePurified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a peptide spanning the cleavage site to remove antibody that is reactive with full length PARP. The final product is generated by

  • Specifications: PARP (cleaved) antibody (FITC)

Full Namepoly (ADP-ribose) polymerase 1
BackgroundPARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARPs N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Synonyms142, pADPRT1, PARP-1, PARP cleaved, PARP, pADPRT-1, P09874, ADPRT1, PARP1, 173870, ADPRT, PPOL, PARP 1, pADPRT 1
Cellular LocalizationNuclear
SpecificityThis antibody specifically recognizes the 85 kDa fragment of cleaved PARP and can be used as a marker for detecting apoptotic cells.
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenSynthetic peptide (Human) corresponding to N-terminus of cleavage site (214/215) of human PARP.
Antigen SpeciesHuman
Species ReactivityHuman, Bovine
ConjugationFITC

  • Storage Conditions: PARP (cleaved) antibody (FITC)

Storage BufferPreservative: 0.1% Sodium Azide; Constituents: PBS, BSA. pH 7.2
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Metastasis and Invasion > Metastasis > Lymphatic
  • Cancer > DNA repair > Base-excision repair
  • Cancer > Type of cancer > Brain > Glioma
  • Cancer > Type of cancer > Breast > Other
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PARP (cleaved) antibody (FITC) validated data
  • Anti-PARP (cleaved) antibody (FITC) used in Flow cytometry/FACS. GTX24831
    • GTX24831 FACS Image
      Apoptosis was induced as described in suggested protocol for apoptosis induction. The cells were fixed, permeabilized and stained with 10 ul/106 cells of the rabbit anti-PARP (214/215) FITC using the staining protocol (left-hand figure).
      Top
  • Anti-PARP (cleaved) antibody (FITC) used in Flow cytometry/FACS. GTX24831
    • GTX24831 FACS Image
      Apoptosis was induced as described in suggested protocol for apoptosis induction. The cells were fixed, permeabilized and stained with 10 ul/106 cells of the rabbit anti-PARP (214/215) FITC using the staining protocol (left-hand figure).
      Top
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