|Full Name||POZ (BTB) and AT hook containing zinc finger 1|
|Product Description||Rabbit Polyclonal antibody to PATZ1 (POZ (BTB) and AT hook containing zinc finger 1)|
|Background||The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq]|
|Synonyms||MAZR antibody, PATZ antibody, RIAZ antibody, ZBTB19 antibody, ZNF278 antibody, ZSG antibody, dJ400N23 antibody, PATZ1 antibody, zinc finger and BTB domain-containing protein 19 antibody, "POZ-, AT hook-, and zinc finger-containing protein 1 antibody", zinc finger sarcoma gene protein antibody, BTB-POZ domain zinc finger transcription factor antibody, POZ-AT hook-zinc finger protein antibody, zinc finger protein 278 antibody, BTB/POZ domain zinc finger transcription factor antibody, protein kinase A RI subunit alpha-associated protein antibody, MAZ-related factor antibody, POZ (BTB) and AT hook containing zinc finger 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PATZ1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Rabbit (99%), Bovine (100%)|