PAX8 antibody, N-term
|Applications||IHC, IHC-P, WB|
|Application Note||Approx 40kDa band observed in Human Liver lysates (calculated MW of xxkDa according to NP_039245.1). Recommended concentration: 1-3µg/ml. In paraffin embedded Human Thyroid Gland shows nuclear staining in epithelial cells around follicles. Recommended concentration, 1-2µg/ml. A customer found this antibody unsuccessful in immunohistochemistry on Mouse tissues. This antibody is expected to recognise all five human isoforms (as represented by NP_003457.1; NP_039245.1; NP_039246.1; NP_039247.1; NP_054698.1)|
|Positive Controls||The peptide used to product this antibody is available for purchase (Catalog Number:GTX13611-PEP).|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.|
|Full Name||paired box 8|
|Product Description||Goat polyclonal antibody to PAX8 (N Terminus)|
|Background||This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described.|
|Synonyms||paired box gene8, PAX8, paired box 8, PAX8 (N Terminus), paired domain gene8, paired domain gene 8, paired box8, paired box gene 8|
|Specificity||This antibody is specific for PAX8 (N Terminus).|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.