|Full Name||hydroxymethylbilane synthase|
|Product Description||Rabbit polyclonal antibody to PBG-D (hydroxymethylbilane synthase)|
|Background||This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]|
|Synonyms||PBG-D antibody, PBGD antibody, PORC antibody, UPS antibody, HMBS antibody, porphobilinogen deaminase antibody, "porphyria, acute, Chester type antibody", uroporphyrinogen I synthetase antibody, uroporphyrinogen I synthase antibody, pre-uroporphyrinogen synthase antibody, hydroxymethylbilane synthase antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PBG-D. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Cat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (92%), Rat (92%), Cat (96%), Pig (95%), Rhesus Monkey (98%), Bovine (93%)|