|Full Name||proprotein convertase subtilisin/kexin type 1|
|Product Description||Rabbit Polyclonal antibody to PC1/3 (proprotein convertase subtilisin/kexin type 1)|
|Background||The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. [provided by RefSeq]|
|Synonyms||BMIQ12 antibody, NEC1 antibody, PC1 antibody, PC3 antibody, SPC3 antibody, PCSK1 antibody, prohormone convertase 1 antibody, prohormone convertase 3 antibody, NEC 1 antibody, neuroendocrine convertase 1 antibody, proprotein convertase subtilisin/kexin type 1 antibody|
|Cellular Localization||Cytoplasmic vesicle , secretory vesicle |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PC1/3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Pig, Bovine|
|Predict Reactivity Note||Rat (100%), Zebrafish (93%), Pig (100%), Bovine (98%)|