|Full Name||protocadherin alpha 6|
|Product Description||Rabbit Polyclonal antibody to PCDHA6 (protocadherin alpha 6)|
|Background||This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq]|
|Synonyms||CNR2 antibody, CNRN2 antibody, CNRS2 antibody, CRNR2 antibody, PCDH-ALPHA6 antibody, PCDHA6 antibody, PCDH-alpha-6 antibody, protocadherin alpha-6 antibody, KIAA0345-like 8 antibody, protocadherin alpha 6 antibody|
|Cellular Localization||Isoform 1: Cell membrane; Single-pass type I membrane protein , Isoform 2: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PCDHA6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (82%), Chimpanzee (98%)|