|Full Name||protocadherin gamma subfamily B, 4|
|Product Description||Rabbit Polyclonal antibody to PCDHGB4 (protocadherin gamma subfamily B, 4)|
|Background||This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq]|
|Synonyms||CDH20 antibody, FIB2 antibody, MGC138293 antibody, MGC142167 antibody, PCDH-GAMMA-B4 antibody, PCDHGB4 antibody, cadherin 20 antibody, fibroblast cadherin-2 antibody, fibroblast cadherin FIB2 antibody, cadherin-20 antibody, protocadherin gamma-B4 antibody, "protocadherin gamma subfamily B, 4 antibody"|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PCDHGB4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (85%), Chimpanzee (100%), Bovine (85%)|