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PD-L2 antibody

Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449
Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449
Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449
Anti-PD-L2 antibody used in Western Blot (WB). GTX85449

Cat. No. GTX85449

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all PD-L2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Positive Control

Raji Cell Lysate(GTX27908) , Mouse Brain Tissue Lysate(GTX27934)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

PD-L2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human PD-L2.The immunogen is located within amino acids 140 - 190 of PD-L2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

programmed cell death 1 ligand 2 , B7DC , Btdc , CD273 , PD-L2 , PDCD1L2 , PDL2 , bA574F11.2

Background

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.

Database

Research Area

DATA IMAGES

Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449

GTX85449 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85449 PD-L2 antibody.
Working concentration : 20 μg/ml

Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449

GTX85449 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85449 PD-L2 antibody.
Working concentration : 2.5 μg/ml

Anti-PD-L2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85449

GTX85449 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85449 PD-L2 antibody.
Working concentration : 2.5 μg/ml

Anti-PD-L2 antibody used in Western Blot (WB). GTX85449

GTX85449 WB Image

WB analysis of Raji cell lysate using GTX85449 PD-L2 antibody.
Working concentration : 0.5 and 1 μg/ml

REFERENCE

Application Reference

Huang N et al. Int J Immunopathol Pharmacol 2021; 35 : 20587384211061051 Splenic CD4+ and CD8+ T-cells highly expressed PD-1 and Tim-3 in cirrhotic patients with HCV infection and portal hypertension.
Application : IHC-P
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399