|Full Name||phosphodiesterase 11A|
|Product Description||Rabbit Polyclonal antibody to PDE11A (phosphodiesterase 11A)|
|Background||The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||FLJ23693 antibody, MGC133355 antibody, MGC133356 antibody, PPNAD2 antibody, PDE11A antibody, "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody", cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody, phosphodiesterase 11A antibody|
|Cellular Localization||Cytoplasm , cytosol |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PDE11A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Bovine (99%)|