|Full Name||phosphodiesterase 4B, cAMP-specific|
|Product Description||Rabbit Polyclonal antibody to PDE4B (phosphodiesterase 4B, cAMP-specific)|
|Background||This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]|
|Synonyms||phosphodiesterase 4B, cAMP-specific Antibody , DPDE4 Antibody , PDE4B5 Antibody , PDEIVB Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PDE4B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (82%), Rat (82%), Pig (97%), Rhesus Monkey (85%), Bovine (83%)|