|Full Name||platelet-derived growth factor receptor, beta polypeptide|
|Product Description||Rabbit Polyclonal antibody to PDGF Receptor beta (platelet-derived growth factor receptor, beta polypeptide)|
|Background||This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq]|
|Synonyms||CD140B antibody, JTK12 antibody, PDGFR antibody, PDGFR1 antibody, PDGFRB antibody, PDGFR-beta antibody, platelet-derived growth factor receptor 1 antibody, PDGF-R-beta antibody, platelet-derived growth factor receptor beta antibody, beta-type platelet-derived growth factor receptor antibody, CD140 antigen-like family member B antibody, "platelet-derived growth factor receptor, beta polypeptide antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PDGF Receptor beta. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Dog (82%), Bovine (80%)|