Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||31 kDa (note)
|Positive Controls||Jurkat , Raji , NCI-H929 , mouse liver , rat liver , AsPC-1 , mouse pancreas|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||pancreatic and duodenal homeobox 1|
|Product Description||Rabbit Polyclonal antibody to PDX1 (pancreatic and duodenal homeobox 1)|
|Background||The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq]|
|Synonyms||pancreatic and duodenal homeobox 1 Antibody , STF-1 Antibody , MODY4 Antibody , IDX-1 Antibody , IPF1 Antibody , PDX-1 Antibody , GSF Antibody , IUF1 Antibody|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PDX1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Dog (100%), Pig (100%)|