|Full Name||PDZ domain containing 1|
|Product Description||Rabbit Polyclonal antibody to PDZK1 (PDZ domain containing 1)|
|Background||A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.|
|Synonyms||CAP70 antibody, CLAMP antibody, NHERF-3 antibody, NHERF3 antibody, PDZD1 antibody, PDZK1 antibody, CFTR-associated protein of 70 kDa antibody, Na(+)/H(+) exchange regulatory cofactor NHE-RF3 antibody, sodium-hydrogen exchanger regulatory factor 3 antibody, PDZ-containing kidney protein 1 antibody, naPi-Cap1 antibody, na/Pi cotransporter C-terminal-associated protein 1 antibody, PDZ domain containing 1 antibody|
|Cellular Localization||Cytoplasm (By similarity) , Membrane; Peripheral membrane protein (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PDZK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rabbit (86%), Bovine (87%)|