|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||33 kDa (note)
|Positive Controls||Raji , K562 , THP-1 , NCI-H929 , mouse liver , PC-12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||peroxisomal biogenesis factor 19|
|Product Description||Rabbit Polyclonal antibody to PEX19 (peroxisomal biogenesis factor 19)|
|Background||This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq]|
|Synonyms||D1S2223E antibody, FLJ55296 antibody, HK33 antibody, PMP1 antibody, PMPI antibody, PXF antibody, PXMP1 antibody, PEX19 antibody, peroxisomal biogenesis factor 19 antibody, peroxisomal farnesylated protein antibody, housekeeping gene, 33kD antibody, 33 kDa housekeeping protein antibody, peroxin-19 antibody|
|Cellular Localization||Cytoplasm , Peroxisome membrane; Lipid-anchor; Cytoplasmic side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PEX19. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (95%)|