|Full Name||peroxisomal biogenesis factor 5|
|Product Description||Rabbit Polyclonal antibody to PEX5 (peroxisomal biogenesis factor 5)|
|Background||The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]|
|Synonyms||FLJ50634 antibody, FLJ50721 antibody, FLJ51948 antibody, PTS1-BP antibody, PTS1R antibody, PXR1 antibody, PEX5 antibody, peroxisomal targeting signal import receptor antibody, PTS1 receptor antibody, peroxisomal targeting signal 1 (SKL type) receptor antibody, peroxisomal C-terminal targeting signal import receptor antibody, peroxin-5 antibody, peroxisomal biogenesis factor 5 antibody, peroxisomal targeting signal receptor 1 antibody, peroxisome receptor 1 antibody, peroxisomal targeting signal 1 receptor antibody|
|Cellular Localization||Cytoplasm , Peroxisome membrane; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PEX5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Guinea pig|
|Predict Reactivity Note||Bovine (97%), Guinea pig (98%)|